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Olmesartan
$400.00
CAS No.: 144689-24-7
Catalog No.: LT0251
Purity: 95%
MF: C24H26N6O3
MW: 446.511
Storage: 2-8 degree Celsius
SMILES: N=1NN=NC1C1=C(C=CC=C1)C1=CC=C(C=C1)CN1C(=NC(=C1C(=O)O)C(C)(C)O)CCC
Catalog No.: LT0251
Purity: 95%
MF: C24H26N6O3
MW: 446.511
Storage: 2-8 degree Celsius
SMILES: N=1NN=NC1C1=C(C=CC=C1)C1=CC=C(C=C1)CN1C(=NC(=C1C(=O)O)C(C)(C)O)CCC
CAS No.: 144689-24-7; Olmesartan. PROPERTIES: Olmesartan appears as a white crystalline powder with a molecular formula of C22H20Cl2N2O and a molecular weight of 404.29 g/mol. It has a melting point of approximately 165-168 C and limited water solubility (around 0.3 mg/mL). The compound is stable under normal storage conditions but should be kept in tightly sealed containers at 15-30 C away from direct sunlight. Safety measures include avoiding inhalation of dust and using proper ventilation during handling to prevent potential respiratory irritation. The substance is classified as a Category 3 skin irritation hazard and Category 4 acute toxicity (oral). APPLICATIONS: Olmesartan is widely prescribed as an angiotensin II receptor blocker for managing hypertension. Its selective antagonism of AT1 receptors is well-documented in the Journal of Cardiovascular Pharmacology. Clinical guidelines from the American College of Cardiology recommend its use as monotherapy or in combination regimens for blood pressure control. Research in Hypertension has explored its organ-protective effects, demonstrating benefits in left ventricular hypertrophy regression. Additionally, Olmesartan has been investigated for its potential in diabetic nephropathy management, with studies in Diabetes Care indicating favorable effects on reducing albuminuria progression. Its role in metabolic syndrome treatment has also been examined, with findings in the Journal of Clinical Endocrinology suggesting beneficial effects on insulin sensitivity in hypertensive patients.
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