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CAS No.: 137862-53-4; Valsartan.PROPERTIES: 3'-O-NH2-2'-dTTP is a modified deoxynucleoside triphosphate with molecular formula C11H17N4O10P3. This colorless viscous liquid has a molecular weight of approximately 468.2 g/mol. It exhibits excellent solubility in aqueous solutions at physiological pH but requires warming for complete dissolution. The compound is sensitive to acid hydrolysis and must be stored at -80 C in small aliquots under argon atmosphere. Safety precautions include wearing chemical-resistant gloves and avoiding skin contact. The 3'-amino modification renders it moderately toxic, and it is classified as a potential reproductive toxin. APPLICATIONS: In oligonucleotide chemistry, 3'-O-NH2-2'-dTTP serves as a building block for creating 3'-amino-modified DNA probes for bioconjugation reactions, as documented in Bioconjugate Chemistry. Its application in developing click chemistry-enabled DNA constructs is reported in Angewandte Chemie. In structural biology, the reagent facilitates creation of crystallographic DNA-protein complexes through site-specific modification, with findings published in Journal of the American Chemical Society. Additionally, it has applications in RNA interference research for synthesizing amino-modified siRNA duplexes, as described in RNA journal.