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Trityl olmesartan medoxomil
$200.00
CAS No.: 144690-92-6
Catalog No.: LT0250
Purity: 95%
MF: C48H44N6O6
MW: 800.916
Storage: 2-8 degree Celsius
SMILES: OC(C)(C)C=1N=C(N(C1C(=O)OCC=1OC(OC1C)=O)CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)CCC
Catalog No.: LT0250
Purity: 95%
MF: C48H44N6O6
MW: 800.916
Storage: 2-8 degree Celsius
SMILES: OC(C)(C)C=1N=C(N(C1C(=O)OCC=1OC(OC1C)=O)CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)CCC
CAS No.: 144690-92-6; Trityl olmesartan medoxomil. PROPERTIES: Trityl olmesartan medoxomil is a white crystalline powder with a molecular weight of 1077.3 g/mol. It has a melting point between 172-176 C and exhibits extremely low water solubility (less than 0.1 mg/mL). The compound is sensitive to hydrolysis and requires storage below 25 C in airtight containers with desiccants. Safety precautions include using powder-free nitrile gloves and safety goggles during handling to prevent eye contact and skin absorption. The substance is classified as a Category 2 eye damage hazard and Category 3 acute toxicity (oral). APPLICATIONS: Trityl olmesartan medoxomil serves as a prodrug form of Olmesartan, designed to enhance bioavailability through protection from premature hydrolysis. Research in the Journal of Pharmaceutical Sciences details its role in hypertensive therapy, where it converts to active Olmesartan in the gastrointestinal tract. Clinical studies in the American Journal of Hypertension demonstrate its effectiveness in reducing systolic and diastolic blood pressure with once-daily dosing. Additionally, the compound has been evaluated for its potential in managing chronic kidney disease associated with hypertension, with studies in Kidney International showing beneficial effects on proteinuria reduction. Its unique prodrug formulation has also been the subject of pharmaceutics research focusing on drug delivery systems for cardiovascular medications.
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