![(S)-methyl 3-methyl-2-(methyl(2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)amino)butanoate](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/l/t/lt0258.jpg)
4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
$300.00
CAS No.: 138401-24-8
Catalog No.: LT0256
Purity: 95%
MF: C25H27N3O
MW: 385.511
Storage: 2-8 degree Celsius
SMILES: C(CCC)C1=NC2(C(N1CC1=CC=C(C=C1)C=1C(=CC=CC1)C#N)=O)CCCC2
Catalog No.: LT0256
Purity: 95%
MF: C25H27N3O
MW: 385.511
Storage: 2-8 degree Celsius
SMILES: C(CCC)C1=NC2(C(N1CC1=CC=C(C=C1)C=1C(=CC=CC1)C#N)=O)CCCC2
CAS NO.: 138401-24-8;4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile. PROPERTIES: This spirocyclic biphenyl nitrile presents as a white crystalline solid with a molecular weight of approximately 393.5 g/mol. The 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile combines a spiro-fused diazaspirocycle with a biphenyl framework and nitrile group. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed spiro-bond cleavage and base-promoted nitrile hydrolysis, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile serves as a key intermediate in the synthesis of various pharmaceuticals. Its spiro-fused diazaspirocycle provides opportunities for constructing complex alkaloids and receptor-targeted molecules. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin-norepinephrine reuptake inhibitors. The biphenyl framework enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating fluorescent probes and bioimaging agents with enhanced photostability.
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