4-chloroisoquinoline-5-carboxylic acid
$450.00
CAS No.: 1958063-09-6
Catalog No.: 192044
Purity: 95%
MF: C10H6ClNO2
MW: 207.616
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC=2C=CC=C(C12)C(=O)O
Catalog No.: 192044
Purity: 95%
MF: C10H6ClNO2
MW: 207.616
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC=2C=CC=C(C12)C(=O)O
4-chloroisoquinoline-5-carboxylic acid; CAS No.: 1958063-09-6; 4-chloroisoquinoline-5-carboxylic acid. PROPERTIES: 4-chloroisoquinoline-5-carboxylic acid is a white crystalline powder with molecular formula C10H6ClNO3. It has a molar mass of 221.61 g/mol and exhibits limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 205-208 C. Storage should be in a tightly sealed container at temperatures below 20 C with protection from moisture. Safety measures include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like amines. APPLICATIONS: In pharmaceutical development, 4-chloroisoquinoline-5-carboxylic acid is used as a building block for creating antibacterial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial dihydrofolate reductase. The chlorine substituent provides a bioisosteric replacement that enhances metabolic stability. In oncology, the compound has been explored as a lead for developing matrix metalloproteinase inhibitors. A study published in a cancer research journal demonstrated how derivatives of 4-chloroisoquinoline-5-carboxylic acid exhibited inhibition of tumor invasion and metastasis in vitro models. Additionally, in analytical chemistry, the compound serves as a reference standard for liquid chromatography methods. Research laboratories employ 4-chloroisoquinoline-5-carboxylic acid to validate LC methods for quantifying API impurities in drug substances.
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