4-chloroisoquinoline
$200.00
CAS No.: 1532-91-8
Catalog No.: 196247
Purity: 95%
MF: C9H6ClN
MW: 163.607
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC2=CC=CC=C12
Catalog No.: 196247
Purity: 95%
MF: C9H6ClN
MW: 163.607
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC2=CC=CC=C12
4-chloroisoquinoline; CAS No.: 1532-91-8; 4-chloroisoquinoline. PROPERTIES: This compound presents a 4-chloroisoquinoline structure, combining a chloro substituent and an isoquinoline framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 159.6 g/mol (C8H5ClN). The melting point ranges between 90-95 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Chloroisoquinoline serves as a specialized intermediate in pharmaceutical research. Its 4-chloroisoquinoline structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro position and electrophilic substitution at the isoquinoline ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The chloro substituent provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-chloroisoquinoline scaffold for improved biological activity and pharmacokinetic properties.
Reviews
Write Your Own Review