8-hydroxyisoquinoline-4-carboxylic acid
$450.00
CAS No.: 1958106-10-9
Catalog No.: 192043
Purity: 95%
MF: C10H7NO3
MW: 189.17
Storage: 2-8 degree Celsius
SMILES: OC=1C=CC=C2C(=CN=CC12)C(=O)O
Catalog No.: 192043
Purity: 95%
MF: C10H7NO3
MW: 189.17
Storage: 2-8 degree Celsius
SMILES: OC=1C=CC=C2C(=CN=CC12)C(=O)O
8-hydroxyisoquinoline-4-carboxylic acid; CAS No.: 1958106-10-9; 8-hydroxyisoquinoline-4-carboxylic acid. PROPERTIES: 8-hydroxyisoquinoline-4-carboxylic acid is a white to off-white crystalline powder with molecular formula C10H7NO4. It has a molar mass of 193.17 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 225-228 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause skin irritation, so washing with soap and water is recommended upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like strong acids. APPLICATIONS: In medicinal chemistry, 8-hydroxyisoquinoline-4-carboxylic acid serves as a key intermediate for developing kinase inhibitors. Research groups at pharmaceutical companies have used this compound to create inhibitors targeting the JAK/STAT signaling pathway in inflammatory diseases. The hydroxyl group provides a hydrogen bond donor that enhances target engagement. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate monoamine transporters. A study published in a medicinal chemistry journal demonstrated how derivatives of 8-hydroxyisoquinoline-4-carboxylic acid exhibited selective inhibition of the serotonin transporter. Additionally, in materials science, the compound's electron-rich hydroxyl group makes it suitable for use in hole-blocking layers of organic photovoltaics. Researchers at a renewable energy laboratory incorporated 8-hydroxyisoquinoline-4-carboxylic acid derivatives into device architectures to improve charge separation efficiencies.
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