methyl 5-hydroxyisoquinoline-4-carboxylate
$400.00
CAS No.: 1958100-72-5
Catalog No.: 192045
Purity: 95%
MF: C11H9NO3
MW: 203.197
Storage: 2-8 degree Celsius
SMILES: OC1=C2C(=CN=CC2=CC=C1)C(=O)OC
Catalog No.: 192045
Purity: 95%
MF: C11H9NO3
MW: 203.197
Storage: 2-8 degree Celsius
SMILES: OC1=C2C(=CN=CC2=CC=C1)C(=O)OC
methyl 5-hydroxyisoquinoline-4-carboxylate; CAS No.: 1958100-72-5; methyl 5-hydroxyisoquinoline-4-carboxylate. PROPERTIES: Methyl 5-hydroxyisoquinoline-4-carboxylate is a pale yellow crystalline solid with molecular formula C11H9NO4. It has a molar mass of 215.20 g/mol and exhibits moderate solubility in ethanol and methanol but limited water solubility. The compound melts between 145-148 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause eye irritation, so immediate rinsing with water is required upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical research, methyl 5-hydroxyisoquinoline-4-carboxylate serves as a key intermediate for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create ATP-competitive inhibitors targeting cancer-related kinases. The methyl ester group provides a metabolically labile moiety that can be hydrolyzed in vivo to release the active carboxylic acid form. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate glutamate receptors. A study published in a neuroscience journal demonstrated how derivatives of methyl 5-hydroxyisoquinoline-4-carboxylate exhibited neuroprotective effects in excitotoxicity models. Additionally, in materials science, the compound's photostable properties make it suitable for use in photographic chemicals. Researchers at an imaging technology company incorporated methyl 5-hydroxyisoquinoline-4-carboxylate derivatives into light-sensitive resins for high-resolution photolithography applications.
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