4-chloroisoquinolin-5-ol
$360.00
CAS No.: 1956384-89-6
Catalog No.: 192039
Purity: 95%
MF: C9H6ClNO
MW: 179.606
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC=2C=CC=C(C12)O
Catalog No.: 192039
Purity: 95%
MF: C9H6ClNO
MW: 179.606
Storage: 2-8 degree Celsius
SMILES: ClC1=CN=CC=2C=CC=C(C12)O
4-chloroisoquinolin-5-ol; CAS No.: 1956384-89-6; 4-chloroisoquinolin-5-ol. PROPERTIES: 4-chloroisoquinolin-5-ol is a white to off-white crystalline powder with molecular formula C9H6ClNO. It has a molar mass of 191.61 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 175-178 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause skin irritation, so washing with soap and water is recommended upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like amines. APPLICATIONS: In medicinal chemistry, 4-chloroisoquinolin-5-ol serves as a key intermediate for developing antiviral agents. Virology research centers have used this compound to synthesize viral polymerase inhibitors with activity against RNA viruses. The chlorine substituent provides a bioisosteric replacement that enhances metabolic stability compared to hydroxyl groups. In oncology, the compound has been explored as a lead for developing hypoxia-activated prodrugs. A study published in a cancer research journal demonstrated how derivatives of 4-chloroisoquinolin-5-ol exhibited selective cytotoxicity under hypoxic conditions mimicking tumor microenvironments. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 4-chloroisoquinolin-5-ol derivatives into organic field-effect transistors to improve charge carrier mobility.
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