4-bromoisoquinolin-8-ol
$360.00
CAS No.: 1784957-23-8
Catalog No.: 192038
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=C(C=CC=C12)O
Catalog No.: 192038
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC2=C(C=CC=C12)O
4-bromoisoquinolin-8-ol; CAS No.: 1784957-23-8; 4-bromoisoquinolin-8-ol. PROPERTIES: 4-bromoisoquinolin-8-ol is a pale yellow crystalline solid with molecular formula C9H6BrNO. It has a molar mass of 244.06 g/mol and exhibits limited water solubility but good solubility in ethanol and acetone. The compound melts between 148-151 C. Storage should be in a tightly sealed container at temperatures below 10 C with protection from light. Safety measures include using powder-free nitrile gloves and safety goggles. The compound may cause respiratory irritation, so handling in a well-ventilated area or fume hood is advised. If swallowed, medical attention should be sought immediately. The material should be stored away from heat sources and incompatible substances. APPLICATIONS: In pharmaceutical research, 4-bromoisoquinolin-8-ol is used as a building block for developing kinase inhibitors. Oncology research centers have utilized this compound to create inhibitors targeting the PI3K/AKT/mTOR pathway in cancer cells. The bromine substituent provides a handle for palladium-catalyzed cross-coupling reactions to introduce aryl groups. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a neuroscience journal demonstrated how derivatives of 4-bromoisoquinolin-8-ol exhibited anxiolytic effects in rodent models of anxiety. Additionally, in analytical chemistry, the compound serves as a reference standard for nuclear magnetic resonance (NMR) spectroscopy. Research laboratories employ 4-bromoisoquinolin-8-ol to validate NMR methods for characterizing isoquinoline alkaloids in natural product extracts.
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