4-bromoisoquinolin-5-ol
$300.00
CAS No.: 651310-41-7
Catalog No.: 192040
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC=2C=CC=C(C12)O
Catalog No.: 192040
Purity: 95%
MF: C9H6BrNO
MW: 224.057
Storage: 2-8 degree Celsius
SMILES: BrC1=CN=CC=2C=CC=C(C12)O
4-bromoisoquinolin-5-ol; CAS No.: 651310-41-7; 4-bromoisoquinolin-5-ol. PROPERTIES: 4-bromoisoquinolin-5-ol is a pale yellow crystalline solid with molecular formula C9H6BrNO. It has a molar mass of 244.06 g/mol and exhibits limited water solubility but good solubility in ethanol and acetone. The compound melts between 152-155 C. Storage should be in a tightly sealed container at temperatures below 10 C with protection from light. Safety measures include using powder-free nitrile gloves and safety goggles. The compound may cause severe eye damage, so immediate rinsing with water for several minutes is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat sources and incompatible substances. APPLICATIONS: In pharmaceutical development, 4-bromoisoquinolin-5-ol is used as a building block for creating kinase inhibitors. Research groups focusing on cancer therapy have utilized this compound to develop inhibitors targeting the MAPK signaling pathway. The bromine substituent facilitates Suzuki coupling reactions for introducing aryl groups with specific effects. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate GABA receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 4-bromoisoquinolin-5-ol exhibited anxiolytic and anticonvulsant activities in rodent models. Additionally, in analytical chemistry, the compound serves as a reference standard for thin-layer chromatography (TLC) methods. Research laboratories employ 4-bromoisoquinolin-5-ol to validate TLC protocols for separating isoquinoline alkaloids in plant extracts.
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