1-(3-aminoquinolin-7-yl)ethanone
$400.00
CAS No.: 1958063-12-1
Catalog No.: 192050
Purity: 95%
MF: C11H10N2O
MW: 186.214
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=CC(=CC=C2C1)C(C)=O
Catalog No.: 192050
Purity: 95%
MF: C11H10N2O
MW: 186.214
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=CC(=CC=C2C1)C(C)=O
1-(3-aminoquinolin-7-yl)ethanone; CAS No.: 1958063-12-1; 1-(3-aminoquinolin-7-yl)ethanone. PROPERTIES: 1-(3-aminoquinolin-7-yl)ethanone is a pale yellow crystalline solid with molecular formula C12H11N3O. It has a molar mass of 221.24 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 165-168 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from moisture. Safety measures include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical development, 1-(3-aminoquinolin-7-yl)ethanone is used as a building block for creating kinase inhibitors. Research groups focusing on cancer therapy have utilized this compound to develop inhibitors targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. The amino group provides a functionality for forming hydrogen bonds with the kinase hinge region. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 1-(3-aminoquinolin-7-yl)ethanone exhibited anxiolytic effects in rodent models of anxiety. Additionally, in analytical chemistry, the compound serves as a reference standard for liquid chromatography-mass spectrometry (LC-MS) methods. Research laboratories employ 1-(3-aminoquinolin-7-yl)ethanone to validate LC-MS protocols for quantifying API impurities in drug substances.
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