3-aminoquinoline-8-carbonitrile
$360.00
CAS No.: 347146-19-4
Catalog No.: 192148
Purity: 95%
MF: C10H7N3
MW: 169.187
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=C(C=CC=C2C1)C#N
Catalog No.: 192148
Purity: 95%
MF: C10H7N3
MW: 169.187
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=C(C=CC=C2C1)C#N
3-aminoquinoline-8-carbonitrile; CAS No.: 347146-19-4; 3-aminoquinoline-8-carbonitrile. PROPERTIES: 3-aminoquinoline-8-carbonitrile is a white crystalline powder with molecular formula C11H8N2. It has a molar mass of 176.19 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 130-133 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical splash goggles and acid-resistant gloves. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In medicinal chemistry, 3-aminoquinoline-8-carbonitrile serves as a building block for developing antimicrobial agents. Research teams at antibiotic development centers have utilized this compound to synthesize inhibitors of bacterial DNA gyrase. The amino group provides a hydrogen bond donor that enhances interactions with the enzyme's active site. In agrochemical research (though not agricultural application), the compound has been explored as a lead for developing antifungal agents that inhibit fungal sterol biosynthesis. A study published in a pesticide chemistry journal demonstrated how derivatives of this compound inhibited fungal growth in vitro. Additionally, in analytical chemistry, the compound serves as a reference standard for capillary electrophoresis methods. Research laboratories employ 3-aminoquinoline-8-carbonitrile to validate electrophoretic protocols for separating basic compounds in complex mixtures.
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