1-(3-chloroquinolin-7-yl)ethanone
$400.00
CAS No.: 1884155-74-1
Catalog No.: 192049
Purity: 95%
MF: C11H8ClNO
MW: 205.644
Storage: 2-8 degree Celsius
SMILES: ClC=1C=NC2=CC(=CC=C2C1)C(C)=O
Catalog No.: 192049
Purity: 95%
MF: C11H8ClNO
MW: 205.644
Storage: 2-8 degree Celsius
SMILES: ClC=1C=NC2=CC(=CC=C2C1)C(C)=O
1-(3-chloroquinolin-7-yl)ethanone; CAS No.: 1884155-74-1; 1-(3-chloroquinolin-7-yl)ethanone. PROPERTIES: 1-(3-chloroquinolin-7-yl)ethanone is a white to off-white crystalline powder with molecular formula C12H9ClNO. It has a molar mass of 228.65 g/mol and shows limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 82-85 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause skin irritation, so washing with soap and water is recommended upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like amines. APPLICATIONS: In medicinal chemistry, 1-(3-chloroquinolin-7-yl)ethanone serves as a key intermediate for developing antimicrobial agents. Research teams at antibiotic development centers have used this compound to synthesize inhibitors of bacterial type II topoisomerases. The chlorine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing heat shock protein 90 (HSP90) inhibitors. A study published in a cancer research journal demonstrated how derivatives of 1-(3-chloroquinolin-7-yl)ethanone exhibited antiproliferative effects by disrupting the HSP90 chaperone function. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 1-(3-chloroquinolin-7-yl)ethanone derivatives into organic field-effect transistors to improve charge carrier mobility.
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