2-(4-fluorophenyl)piperazine
$300.00
CAS No.: 65709-33-3
Catalog No.: 196290
Purity: 95%
MF: C10H13FN2
MW: 180.226
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)C1NCCNC1
Catalog No.: 196290
Purity: 95%
MF: C10H13FN2
MW: 180.226
Storage: 2-8 degree Celsius
SMILES: FC1=CC=C(C=C1)C1NCCNC1
2-(4-fluorophenyl)piperazine; CAS No.: 65709-33-3; 2-(4-fluorophenyl)piperazine. PROPERTIES: This compound presents a 2-(4-fluorophenyl)piperazine structure, combining a fluorophenyl substituent and a piperazine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 193.2 g/mol (C10H12FN3). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 2-(4-Fluorophenyl)piperazine serves as a specialized intermediate in pharmaceutical research. Its 2-(4-fluorophenyl)piperazine structure enables diverse reactivity patterns, including nucleophilic substitution at the piperazine nitrogen and electrophilic substitution at the fluorophenyl ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The fluorophenyl substituent provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent probes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 2-(4-fluorophenyl)piperazine scaffold for improved biological activity and pharmacokinetic properties.
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