(4-bromo-2-methyl-phenyl)-(4-methyl-piperazin-1-yl)-methanone
$550.00
CAS No.: 924642-59-1
Catalog No.: 196895
Purity: 95%
MF: C13H17BrN2O
MW: 297.196
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)C(=O)N1CCN(CC1)C)C
Catalog No.: 196895
Purity: 95%
MF: C13H17BrN2O
MW: 297.196
Storage: 2-8 degree Celsius
SMILES: BrC1=CC(=C(C=C1)C(=O)N1CCN(CC1)C)C
(4-bromo-2-methyl-phenyl)-(4-methyl-piperazin-1-yl)-methanone; CAS No.: 924642-59-1; (4-bromo-2-methyl-phenyl)-(4-methyl-piperazin-1-yl)-methanone. PROPERTIES: This bromo-methyl-substituted phenyl piperazinyl ketone features molecular formula C??H??BrN?O with molecular weight 314.20 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 100-105 C. Exhibits IR absorption for ketone (~1700 cm??) and C-Br groups (~600-500 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a bromo-methyl-substituted phenyl piperazinyl ketone, (4-bromo-2-methyl-phenyl)-(4-methyl-piperazin-1-yl)-methanone is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the piperazinyl group provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ketone functionality enables conjugation to biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo and methyl substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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