2-(4-chlorophenyl)piperazine dihydrochloride
$300.00
CAS No.: 1185157-51-0
Catalog No.: 192768
Purity: 95%
MF: C10H15Cl3N2
MW: 269.603
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.ClC1=CC=C(C=C1)C1NCCNC1
Catalog No.: 192768
Purity: 95%
MF: C10H15Cl3N2
MW: 269.603
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.ClC1=CC=C(C=C1)C1NCCNC1
2-(4-chlorophenyl)piperazine dihydrochloride; CAS No.: 1185157-51-0; 2-(4-chlorophenyl)piperazine dihydrochloride. PROPERTIES: This chloro-substituted piperazine salt has molecular formula C11H14Cl2N2 {2HCl. It typically appears as a white crystalline powder. The 2-(4-chlorophenyl)piperazine dihydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 200-205 C (with decomposition), and it has a molecular weight of approximately 252.56 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The dihydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 2-(4-chlorophenyl)piperazine dihydrochloride serves as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as reported in medicinal chemistry literature). The chlorophenyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of agrochemicals with herbicidal activity, though this application is mentioned only for informational purposes per your request. The amine group can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.
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