![1-((2'-carbamimidoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/l/t/lt0171.jpg)
2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid
$400.00
CAS No.: 1442400-68-1
Catalog No.: LT0170
Purity: 95%
MF: C23H16N4O5
MW: 428.404
Storage: 2-8 degree Celsius
SMILES: O=C1N(C2=C(N1)C=CC=C2C(=O)O)CC2=CC=C(C=C2)C2=C(C=CC=C2)C2=NOC(N2)=O
Catalog No.: LT0170
Purity: 95%
MF: C23H16N4O5
MW: 428.404
Storage: 2-8 degree Celsius
SMILES: O=C1N(C2=C(N1)C=CC=C2C(=O)O)CC2=CC=C(C=C2)C2=C(C=CC=C2)C2=NOC(N2)=O
CAS NO.: 1442400-68-1;2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid. PROPERTIES: This oxadiazolyl biphenyl carboxylic acid presents as a white crystalline solid with a molecular weight of approximately 494.5 g/mol. The 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid combines a biphenyl framework with oxadiazole, benzoimidazole, and carboxylic acid functionalities. It exhibits limited aqueous solubility until pH < 4 but dissolves well in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ester hydrolysis and base-promoted decarboxylation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its biphenyl framework provides opportunities for constructing complex aromatic systems through Suzuki-Miyaura cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The benzoimidazole carboxylic acid group undergoes esterification or amide bond formation for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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