trans-4-Fluoropyrrolidine-2-carboxylic acid
$400.00
CAS No.: 21156-44-5
Catalog No.: 196485
Purity: 95%
MF: C5H8FNO2
MW: 133.122
Storage: 2-8 degree Celsius
SMILES: F[C@H]1C[C@@H](NC1)C(=O)O
Catalog No.: 196485
Purity: 95%
MF: C5H8FNO2
MW: 133.122
Storage: 2-8 degree Celsius
SMILES: F[C@H]1C[C@@H](NC1)C(=O)O
trans-4-Fluoropyrrolidine-2-carboxylic acid; CAS No.: 21156-44-5; trans-4-Fluoropyrrolidine-2-carboxylic acid. PROPERTIES: trans-4-Fluoropyrrolidine-2-carboxylic acid is a crystalline solid with a characteristic carboxylic acid odor. Its molecular formula is C5H7FNO2, and it possesses a molecular weight of 132.11 g/mol. The compound demonstrates good solubility in polar solvents such as water, methanol, and ethyl acetate, but limited solubility in non-polar solvents. It has a melting point ranging from 145-150 C and is stable under ambient conditions when stored properly. Recommended storage involves keeping the material in a tightly sealed container at room temperature (15-25 C), preferably in a cool, dry place away from direct sunlight and moisture. The compound is hygroscopic to some extent and should be protected from excessive humidity. Safety precautions include wearing appropriate personal protective equipment, such as chemical-resistant gloves and eye protection, when handling the material. In case of skin contact, thorough washing with soap and water is recommended, and eye contact requires immediate rinsing with water for at least 15 minutes followed by medical attention if necessary. The compound should be handled in well-ventilated areas to avoid inhalation of dust particles. APPLICATIONS: trans-4-Fluoropyrrolidine-2-carboxylic acid finds extensive application in the pharmaceutical industry as a building block for peptide synthesis and as a precursor to bioactive molecules. The presence of the fluorine atom introduces unique electronic properties that enhance binding affinity in drug-receptor interactions. In medicinal chemistry, the compound has been utilized in the development of novel antimicrobial agents and as a component in peptidomimetic design, as documented in various pharmaceutical research publications. Its structural features make it suitable for incorporation into beta-turn mimetics and as a surrogate for amino acid residues in constrained peptides. Additionally, trans-4-Fluoropyrrolidine-2-carboxylic acid serves as a valuable intermediate in the synthesis of fluorinated heterocycles for imaging agents and in the development of enzyme inhibitors targeting specific metabolic pathways. The compound's utility extends to materials science, where derivatives have been explored for their potential in liquid crystal applications and as chiral auxiliaries in asymmetric synthesis. Its compatibility with various coupling reagents and protective group strategies makes it a versatile tool in both academic and industrial chemical research settings.
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