tert-butyl 3-(3-oxopiperazin-1-yl)azetidine-1-carboxylate
$405.00
CAS No.: 1257293-71-2
Catalog No.: 192773
Purity: 95%
MF: C12H21N3O3
MW: 255.318
Storage: 2-8 degree Celsius
SMILES: O=C1CN(CCN1)C1CN(C1)C(=O)OC(C)(C)C
Catalog No.: 192773
Purity: 95%
MF: C12H21N3O3
MW: 255.318
Storage: 2-8 degree Celsius
SMILES: O=C1CN(CCN1)C1CN(C1)C(=O)OC(C)(C)C
tert-butyl 3-(3-oxopiperazin-1-yl)azetidine-1-carboxylate; CAS No.: 1257293-71-2; tert-butyl 3-(3-oxopiperazin-1-yl)azetidine-1-carboxylate. PROPERTIES: This oxo-substituted piperazine azetidine carbamate has molecular formula C12H20N3O3. It generally appears as a white crystalline powder. The tert-butyl 3-(3-oxopiperazin-1-yl)azetidine-1-carboxylate demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 90-95 C, and it has a molecular weight of approximately 268.31 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may undergo carbamate hydrolysis upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The tert-butyl 3-(3-oxopiperazin-1-yl)azetidine-1-carboxylate functions as a key intermediate in the synthesis of HIV protease inhibitors where the piperazine group provides essential hydrogen bonding interactions with enzyme residues (as detailed in medicinal chemistry literature). The azetidine ring forms additional hydrogen bonds with catalytic residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the carbamate group reacts with targeting moieties, as described in pharmaceutical sciences journals. The carbamate group can be further functionalized through hydrolysis or alkylation reactions to produce various derivatives for chemical research applications.
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