(R)-3-phenylpiperazin-2-one
$313.00
CAS No.: 1240585-54-9
Catalog No.: 192772
Purity: 95%
MF: C10H12N2O
MW: 176.219
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)[C@@H]1C(NCCN1)=O
Catalog No.: 192772
Purity: 95%
MF: C10H12N2O
MW: 176.219
Storage: 2-8 degree Celsius
SMILES: C1(=CC=CC=C1)[C@@H]1C(NCCN1)=O
(R)-3-phenylpiperazin-2-one; CAS No.: 1240585-54-9; (R)-3-phenylpiperazin-2-one. PROPERTIES: This phenyl-substituted piperazinone has molecular formula C11H12N2O. It typically appears as a white crystalline powder. The (R)-3-phenylpiperazin-2-one demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 130-135 C, and it has a molecular weight of approximately 192.23 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding amine upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The (R)-3-phenylpiperazin-2-one serves as a valuable intermediate in the synthesis of kinase inhibitors for cancer therapy where the piperazinone ring provides essential hydrogen bonding interactions with kinase residues (as reported in medicinal chemistry literature). The phenyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The ketone group can be further functionalized through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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