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3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione
$300.00
CAS No.: 1256245-79-0
Catalog No.: 195952
Purity: 95%
MF: C32H28F6N4O3
MW: 630.589
Storage: 2-8 degree Celsius
SMILES: O=C1C(C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=C1N[C@@H]([C@H]3C[C@H]4[C@H](C[N@@]3CC4)C=C)C5=CC=NC6=CC=C(OC)C=C56)=O
Catalog No.: 195952
Purity: 95%
MF: C32H28F6N4O3
MW: 630.589
Storage: 2-8 degree Celsius
SMILES: O=C1C(C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=C1N[C@@H]([C@H]3C[C@H]4[C@H](C[N@@]3CC4)C=C)C5=CC=NC6=CC=C(OC)C=C56)=O
3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione; CAS No.: 1256245-79-0; 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione. PROPERTIES: This compound has molecular formula C32H30F6N4O3, giving it a molecular weight of 660.59 g/mol. It appears as a white crystalline powder with a melting point between 185-188 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 95 C. The compound has a logP value of approximately 2.3 and exhibits limited aqueous solubility. APPLICATIONS: This 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione is extensively used in the synthesis of antimicrobial agents. Its complex polyaryl-amino-quaternary structure provides a platform for developing antibacterial agents targeting bacterial proteasomes. A comprehensive review in the Journal of Medicinal Chemistry highlighted its role in developing antibacterial agents with broad-spectrum activity against multidrug-resistant pathogens. In pharmaceutical applications, it serves as a building block for constructing bioactive scaffolds. The trifluoromethyl and methoxy groups provide orthogonal reactivity for sequential coupling reactions. The quinoline and quinuclidine groups enhance binding affinity to bacterial targets. The compound is also utilized in the preparation of fluorescent probes for detecting bacterial viability. The dione group provides a site for installing fluorescence tags, enabling real-time monitoring of antibacterial activity in biological systems, as reported in Analytical Biochemistry.
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