4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexan-1-one
$300.00
CAS No.: 857651-06-0
Catalog No.: 195951
Purity: 95%
MF: C15H15N3O2
MW: 269.304
Storage: 2-8 degree Celsius
SMILES: OC1(CCC(CC1)=O)C1=NC=C(C=C1)C1=NC=CC=N1
Catalog No.: 195951
Purity: 95%
MF: C15H15N3O2
MW: 269.304
Storage: 2-8 degree Celsius
SMILES: OC1(CCC(CC1)=O)C1=NC=C(C=C1)C1=NC=CC=N1
4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexan-1-one; CAS No.: 857651-06-0; 4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexan-1-one. PROPERTIES: 4-Hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexan-1-one has molecular formula C15H14N2O2, giving it a molecular weight of 266.29 g/mol. It appears as a white crystalline powder with a melting point between 145-148 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong nucleophilic attack. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.9 and exhibits moderate aqueous solubility. APPLICATIONS: This 4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexan-1-one is extensively used in the synthesis of antimicrobial agents. Its cyclohexanone-pyrimidine-pyridine structure provides a platform for developing antibacterial agents targeting bacterial DNA gyrase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against Gram-negative pathogens. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The pyrimidine and pyridine groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The ketone group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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