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5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole
$400.00
CAS No.: 1103501-11-6
Catalog No.: 195960
Purity: 95%
MF: C18H20Cl2N2O2
MW: 367.276
Storage: 2-8 degree Celsius
SMILES: C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC1CCNCC1
Catalog No.: 195960
Purity: 95%
MF: C18H20Cl2N2O2
MW: 367.276
Storage: 2-8 degree Celsius
SMILES: C1(CC1)C1=C(C(=NO1)C1=C(C=CC=C1Cl)Cl)COC1CCNCC1
5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole; CAS No.: 1103501-11-6; 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole. PROPERTIES: This compound has molecular formula C24H21Cl2N3O2, giving it a molecular weight of 472.35 g/mol. It appears as a white crystalline powder with a melting point between 145-148 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 2.8 and exhibits limited aqueous solubility. APPLICATIONS: This 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((piperidin-4-yloxy)methyl)isoxazole is extensively used in the synthesis of antimicrobial agents. Its isoxazole-piperidine-dichlorophenyl structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The cyclopropyl and dichlorophenyl groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The piperidinyl-oxy group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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