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(R)-1-phenylbut-3-en-2-amine hydrochloride; CAS No.: 244092-64-6 (R)-1-phenylbut-3-en-2-amine hydrochloride. PROPERTIES: (R)-1-phenylbut-3-en-2-amine hydrochloride is a crystalline powder with a molecular weight of 221.7 g/mol. It has a melting point between 185-190 C and is highly soluble in water. The compound exhibits typical amine reactivity and should be handled with care to prevent exposure to moisture, as the hydrochloride salt is hygroscopic. When working with (R)-1-phenylbut-3-en-2-amine hydrochloride, protective equipment including chemical-resistant gloves and a respirator is recommended. Storage should be in a tightly sealed container at 2-8 C, preferably under anhydrous conditions. The compound is sensitive to light and should be protected from direct sunlight. APPLICATIONS: The chiral structure of (R)-1-phenylbut-3-en-2-amine hydrochloride makes it valuable in asymmetric synthesis applications. Its enamine functionality allows for participation in Michael addition reactions, as demonstrated in Organic Letters. Derivatives of this compound have been explored in the development of beta-blockers and other cardiovascular pharmaceuticals, as reported in the Journal of Medicinal Chemistry. The compound also serves as a building block for the synthesis of advanced materials such as chiral catalysts and ligands, as highlighted in Advanced Synthesis & Catalysis. Additionally, it can be utilized in the preparation of fluorescent probes for bioimaging, as described in Chemical Communications.