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(E)-methyl3-(4-(trifluoromethyl)phenyl)acrylate; CAS No.: 20754-22-7 (E)-methyl3-(4-(trifluoromethyl)phenyl)acrylate. PROPERTIES: (E)-methyl3-(4-(trifluoromethyl)phenyl)acrylate is a colorless liquid with a molecular weight of 222.1 g/mol. It has a distinctive fruity odor and a boiling point around 210-215 C at atmospheric pressure. The compound is moderately soluble in water but highly soluble in organic solvents such as ether and chloroform. When handling (E)-methyl3-(4-(trifluoromethyl)phenyl)acrylate, it is important to work in a fume hood due to its volatility. The compound should be stored in tightly sealed containers at temperatures below 10 C to prevent polymerization. Exposure to light should be minimized, and it is advisable to add a stabilizer such as hydroquinone to inhibit spontaneous polymerization. APPLICATIONS: (E)-methyl3-(4-(trifluoromethyl)phenyl)acrylate is widely used in the polymer industry as a monomer for producing specialty polymers with thermal stability and optical clarity. Its trifluoromethyl group imparts unique electronic properties, making it suitable for applications in high-performance coatings, as reported in Polymer Chemistry. In pharmaceutical research, derivatives of this compound have been explored for their potential in developing non-nucleoside reverse transcriptase inhibitors, as documented in the Journal of Medicinal Chemistry. The compound also serves as a valuable intermediate in the synthesis of agrochemicals, though applications are directed toward non-agricultural uses such as in the preparation of specialty surfactants and adhesives, as highlighted in the Journal of Applied Polymer Science.