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3-bromo-6-fluoro-2-hydroxy-benzaldehyde; CAS No.: 199287-82-6 3-bromo-6-fluoro-2-hydroxy-benzaldehyde. PROPERTIES: 3-bromo-6-fluoro-2-hydroxy-benzaldehyde is a crystalline solid with a molecular weight of 235.0 g/mol. It has a melting point in the range of 85-90 C and is moderately soluble in polar organic solvents like methanol and acetone. The compound exhibits weak acidity due to the hydroxyl group and can form complexes with metal ions. When handling 3-bromo-6-fluoro-2-hydroxy-benzaldehyde, care should be taken to avoid moisture, as it may cause hydrolysis. It should be stored in a desiccator with a drying agent at temperatures below 5 C. The compound is light-sensitive and should be protected from direct sunlight. Proper protective equipment including N95 masks and chemical splash goggles is recommended. APPLICATIONS: 3-bromo-6-fluoro-2-hydroxy-benzaldehyde is extensively used as a building block in the synthesis of pharmaceuticals, particularly in the development of anticancer and antimicrobial agents. Its multifunctional structure allows for diverse chemical transformations, as demonstrated in the synthesis of flavonoid analogs reported in Bioorganic & Medicinal Chemistry. The bromine substituent provides a useful handle for cross-coupling reactions, enabling the preparation of various substituted aromatic systems. In materials science, derivatives of this compound have been investigated for their potential in organic electronics, as described in Advanced Materials. Additionally, 3-bromo-6-fluoro-2-hydroxy-benzaldehyde serves as a starting material for the preparation of agrochemical intermediates, though applications are focused on non-agricultural uses such as specialty chemical synthesis, as noted in the Journal of Heterocyclic Chemistry.