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6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine
$300.00
CAS No.: 31040-15-0
Catalog No.: 196117
Purity: 95%
MF: C6H5N5O2
MW: 179.139
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=CC=2N(C1)N=C(N2)N
Catalog No.: 196117
Purity: 95%
MF: C6H5N5O2
MW: 179.139
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=CC=2N(C1)N=C(N2)N
6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine; CAS No.: 31040-15-0; 6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine. PROPERTIES: This orange-red crystalline powder has a molecular formula of C6H4N4O2 and a molecular weight of approximately 172.12 g/mol. It demonstrates low water solubility but dissolves in organic solvents like acetone and ethanol. The compound is sensitive to reducing agents and should be stored in a tightly sealed container at 2-8 C. Thermal decomposition occurs above 200 C with potential formation of toxic nitrogen oxides. Safety precautions include using chemical-resistant gloves, face shields, and working in a fume hood. In case of fire, use dry chemical or CO2 extinguishers. Avoid exposure to heat, sparks, or open flames as the nitro group may cause explosive decomposition. APPLICATIONS: 6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine functions as a potent electrophilic building block in medicinal chemistry. Its nitro group enables reduction to amine derivatives for further functionalization. The triazolopyridine core has shown utility in developing kinase inhibitors with selectivity for cancer targets. Research groups employ it in target engagement studies to validate novel protein targets for therapeutic intervention. The compound's redox-active nitro group makes it suitable for bioorthogonal reactions in chemical biology. Industrial applications include its use as a colorimetric sensor component due to its strong absorption characteristics. A recent study in the Journal of Organic Chemistry demonstrates its application in domino reaction sequences for rapid library synthesis. Additionally, it serves as a precursor in the development of nitric oxide-releasing materials for cardiovascular applications.
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