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6-bromo[1,2,4]triazolo[4,3-a]pyridine
$250.00
CAS No.: 108281-79-4
Catalog No.: 196116
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC=2N(C1)C=NN2
Catalog No.: 196116
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC=1C=CC=2N(C1)C=NN2
6-bromo[1,2,4]triazolo[4,3-a]pyridine; CAS No.: 108281-79-4; 6-bromo[1,2,4]triazolo[4,3-a]pyridine. PROPERTIES: This pale yellow solid has a molecular formula of C6H3BrN4 and a molecular weight of approximately 213.02 g/mol. It exhibits poor water solubility but dissolves readily in DMSO and DMF. The compound is sensitive to basic conditions and should be stored below 20 C in an amber glass bottle to protect from light. Thermogravimetric analysis shows weight loss starting at 220 C. Safety measures include using chemical splash goggles, lab coats, and NIOSH-certified respirators. In case of skin contact, wash with soap and water and remove contaminated clothing. Avoid inhaling dust as it may cause respiratory irritation. APPLICATIONS: 6-bromo[1,2,4]triazolo[4,3-a]pyridine serves as a versatile intermediate in heterocyclic chemistry, particularly in the synthesis of bioactive molecules. Its bromine substituent enables Suzuki-Miyaura cross-coupling reactions for creating diverse substituent patterns. Pharmaceutical researchers utilize it in the development of CNS-active compounds due to the privileged triazolopyridine scaffold. Academic groups employ it in photophysical studies to understand structure-property relationships in luminescent materials. The compound's electron-deficient nature makes it suitable for covalent inhibitor design targeting cysteine residues in proteins. Recent publications in Bioorganic & Medicinal Chemistry highlight its role in fragment-based drug discovery approaches. Additionally, it finds applications in agrochemical research for developing novel herbicide and fungicide candidates with improved efficacy profiles.
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