4-(3-fluorophenyl)tetrahydro-2H-thiopyran-4-carboxylic acid 1,1-dioxide
$400.00
CAS No.: 2490705-21-8
Catalog No.: LT0027
Purity: 95%
MF: C12H13FO4S
MW: 272.297
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1)C1(CCS(CC1)(=O)=O)C(=O)O
Catalog No.: LT0027
Purity: 95%
MF: C12H13FO4S
MW: 272.297
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1)C1(CCS(CC1)(=O)=O)C(=O)O
CAS NO.: 2490705-21-8;4-(3-fluorophenyl)tetrahydro-2H-thiopyran-4-carboxylic acid 1,1-dioxide. PROPERTIES: This fluorinated sulfur-containing acid presents as a white crystalline solid with a molecular weight of approximately 251.3 g/mol. The 4-(3-fluorophenyl)tetrahydro-2H-thiopyran-4-carboxylic acid 1,1-dioxide combines a fluorophenyl group with a thiopyran sulfone framework. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to base-catalyzed hydrolysis of the ester group and light exposure, necessitating storage at 2-8 degree Celsius in amber glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause mild irritation requiring thorough washing. Inhalation may induce respiratory tract irritation; treatment includes fresh air and medical evaluation. Eye exposure requires extended rinsing and possible corticosteroid application. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-(3-fluorophenyl)tetrahydro-2H-thiopyran-4-carboxylic acid 1,1-dioxide serves as a key intermediate in the synthesis of various pharmaceuticals. Its thiopyran sulfone framework provides opportunities for oxidative ring-opening reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and muscarinic receptor modulators. The fluorophenyl group enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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