4-amino-4-(3-fluorophenyl)tetrahydro-2H-thiopyran 1,1-dioxide
$400.00
CAS No.: 2275871-59-3
Catalog No.: LT0026
Purity: 95%
MF: C11H14FNO2S
MW: 243.303
Storage: 2-8 degree Celsius
SMILES: NC1(CCS(CC1)(=O)=O)C1=CC(=CC=C1)F
Catalog No.: LT0026
Purity: 95%
MF: C11H14FNO2S
MW: 243.303
Storage: 2-8 degree Celsius
SMILES: NC1(CCS(CC1)(=O)=O)C1=CC(=CC=C1)F
CAS NO.: 2275871-59-3;4-amino-4-(3-fluorophenyl)tetrahydro-2H-thiopyran 1,1-dioxide. PROPERTIES: This fluorinated sulfur-containing amine presents as a white crystalline solid with a molecular weight of approximately 254.3 g/mol. The 4-amino-4-(3-fluorophenyl)tetrahydro-2H-thiopyran 1,1-dioxide combines a fluorophenyl group with a thiopyran sulfone framework and amino functionality. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed ring-opening and base-promoted hydrolysis of the sulfone group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-amino-4-(3-fluorophenyl)tetrahydro-2H-thiopyran 1,1-dioxide serves as a key intermediate in the synthesis of various pharmaceuticals. Its thiopyran sulfone framework provides opportunities for oxidative ring-opening reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and muscarinic receptor modulators. The fluorophenyl group enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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