4-(thiazol-2-yl)phenol
$400.00
CAS No.: 81015-49-8
Catalog No.: 196061
Purity: 95%
MF: C9H7NOS
MW: 177.228
Storage: 2-8 degree Celsius
SMILES: S1C(=NC=C1)C1=CC=C(C=C1)O
Catalog No.: 196061
Purity: 95%
MF: C9H7NOS
MW: 177.228
Storage: 2-8 degree Celsius
SMILES: S1C(=NC=C1)C1=CC=C(C=C1)O
4-(thiazol-2-yl)phenol; CAS No.: 81015-49-8; 4-(thiazol-2-yl)phenol. PROPERTIES: 4-(thiazol-2-yl)phenol is a crystalline solid with a molecular weight of approximately 183.2 g/mol. It has a melting point between 110-115 C and a boiling point around 280 C at 760 mmHg. The compound is sparingly soluble in water but dissolves readily in organic solvents like methanol and acetone. It exhibits pH-dependent solubility with increased solubility in basic media due to deprotonation of the phenolic hydroxyl group. The compound is sensitive to air oxidation, which may lead to discoloration. Proper storage requires anhydrous conditions in amber glass containers at 2-8 C. Safety: This compound may cause skin sensitization and has potential aquatic toxicity. Avoid release into the environment and use appropriate containment measures. In case of accidental spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: In the field of pharmaceuticals, 4-(thiazol-2-yl)phenol is utilized as a starting material for synthesizing nonsteroidal anti-inflammatory drugs. The thiazole ring enhances the pharmacokinetic properties by improving metabolic stability. In materials science, it serves as a building block for creating electroactive polymers. The phenolic hydroxyl group can undergo etherification or esterification to introduce functional groups that modulate electrical conductivity. In analytical chemistry, it is used as a chromogenic reagent for detecting certain metal ions. The reaction with metal ions produces colored complexes that can be quantified spectrophotometrically. These applications are described in pharmaceutical literature and materials science research articles.
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