methyl 4-methoxy-2-(4-(trifluoromethyl)phenyl)quinoline-7-carboxylate
$360.00
CAS No.: 2842029-93-8
Catalog No.: 197610
Purity: 95%
MF: C19H14F3NO3
MW: 361.319
Storage: 2-8 degree Celsius
SMILES: COC1=CC(=NC2=CC(=CC=C12)C(=O)OC)C1=CC=C(C=C1)C(F)(F)F
Catalog No.: 197610
Purity: 95%
MF: C19H14F3NO3
MW: 361.319
Storage: 2-8 degree Celsius
SMILES: COC1=CC(=NC2=CC(=CC=C12)C(=O)OC)C1=CC=C(C=C1)C(F)(F)F
methyl 4-methoxy-2-(4-(trifluoromethyl)phenyl)quinoline-7-carboxylate; CAS No.: 2842029-93-8;methyl 4-methoxy-2-(4-(trifluoromethyl)phenyl)quinoline-7-carboxylate. PROPERTIES: Methyl 4-methoxy-2-(4-(trifluoromethyl)phenyl)quinoline-7-carboxylate is a substituted quinoline ester with a molecular weight of 397.38 g/mol. This pale yellow crystalline solid has a melting point ranging from 115-118 C. The quinoline ring features a methoxy group at position 4 and is fused at position 2 to a phenyl ring substituted with a trifluoromethyl group at its para position. The carboxylate function at position 7 is esterified to methyl. It exhibits good solubility in common organic solvents such as ethyl acetate and tetrahydrofuran but limited water solubility. Proper storage requires keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the trifluoromethyl group's potential to release toxic fumes when heated and the ester group's flammability. Standard protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of anticancer and antiviral medications, where the trifluoromethylphenyl substituent enhances target binding and the methoxy group modulates electronic properties. In medicinal chemistry, it has been employed in the synthesis of kinase inhibitors and has shown promise in developing protease inhibitors for HIV therapy. The quinoline-7-carboxylate ester structure also finds application in the preparation of fluorescent probes for bioimaging, particularly in monitoring enzyme activities where the trifluoromethyl group affects solubility and the methoxy group influences fluorescence characteristics. These applications are supported by research published in the Journal of Medicinal Chemistry and Chemical Communications.
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