4-methoxy-7-(methoxycarbonyl)quinoline 1-oxide
$200.00
CAS No.: 2842029-91-6
Catalog No.: 197609
Purity: 95%
MF: C12H11NO4
MW: 233.223
Storage: 2-8 degree Celsius
SMILES: COC1=CC=[N+](C2=CC(=CC=C12)C(=O)OC)[O-]
Catalog No.: 197609
Purity: 95%
MF: C12H11NO4
MW: 233.223
Storage: 2-8 degree Celsius
SMILES: COC1=CC=[N+](C2=CC(=CC=C12)C(=O)OC)[O-]
4-methoxy-7-(methoxycarbonyl)quinoline 1-oxide; CAS No.: 2842029-91-6;4-methoxy-7-(methoxycarbonyl)quinoline 1-oxide. PROPERTIES: 4-methoxy-7-(methoxycarbonyl)quinoline 1-oxide is a quinoline N-oxide derivative with a molecular weight of 263.26 g/mol. This yellow crystalline solid features a quinoline ring with a methoxy group at position 4 and a methoxycarbonyl group at position 7, with the nitrogen atom oxidized to form a quinoline 1-oxide structure. It has a melting point between 142-145 C and demonstrates moderate solubility in polar organic solvents such as methanol and acetone while being sparingly soluble in water. The compound should be stored in a cool, dry place in tightly sealed containers, preferably at temperatures below 30 C. Safety considerations include the methoxycarbonyl group's potential to release dimethyl carbonate under acidic conditions and the N-oxide group's moderate toxicity. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of cardiovascular and central nervous system medications, where the N-oxide group enhances water solubility and the methoxycarbonyl function provides sites for further derivatization. In pharmaceutical development, it has been employed in the synthesis of angiotensin receptor blockers and has shown utility in creating monoamine oxidase inhibitors for treating neurological disorders. The quinoline 1-oxide structure has also been explored in agrochemical formulations as a component of fungicides targeting plant pathogens. These applications are detailed in publications from the Journal of Medicinal Chemistry and Pesticide Biochemistry and Physiology.
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