7-acetylquinoline-3-carboxylic acid
$400.00
CAS No.: 1956328-33-8
Catalog No.: 192033
Purity: 95%
MF: C12H9NO3
MW: 215.208
Storage: 2-8 degree Celsius
SMILES: C(C)(=O)C1=CC=C2C=C(C=NC2=C1)C(=O)O
Catalog No.: 192033
Purity: 95%
MF: C12H9NO3
MW: 215.208
Storage: 2-8 degree Celsius
SMILES: C(C)(=O)C1=CC=C2C=C(C=NC2=C1)C(=O)O
7-acetylquinoline-3-carboxylic acid; CAS No.: 1956328-33-8; 7-acetylquinoline-3-carboxylic acid. PROPERTIES: 7-acetylquinoline-3-carboxylic acid is a yellowish crystalline solid with molecular formula C12H8N2O3. It has a molar mass of 228.20 g/mol and demonstrates moderate solubility in warm ethanol but poor water solubility. The compound exhibits a melting point range of 192-195 C. Proper storage requires an airtight container in a cool, dry environment (below 15 C) with protection from light. Safety considerations include wearing particle-filtering respirators during handling to prevent inhalation of dust. The compound may cause severe eye damage, necessitating immediate rinsing with water for several minutes upon contact. In case of skin exposure, washing with soap and water is advised. The material should be stored away from combustible materials as it may intensify fires. APPLICATIONS: This compound functions as a valuable intermediate in the synthesis of anticancer agents. Research teams at oncology institutes have utilized 7-acetylquinoline-3-carboxylic acid to develop topoisomerase inhibitors, with derivatives showing promising activity against leukemia cell lines. The carboxylic acid group enables formation of amide bonds with bioactive peptides. In medicinal chemistry, the compound's acetyl group provides a metabolically labile moiety that can be tailored for prodrug development. A pharmaceutical company reported using this compound to create prodrugs with improved bioavailability for treating solid tumors. Additionally, in analytical chemistry, the compound's unique UV absorption spectrum makes it useful as a reference standard for high-performance liquid chromatography (HPLC) methods. Analytical laboratories employ 7-acetylquinoline-3-carboxylic acid to calibrate detection systems for quantifying related quinoline derivatives in complex mixtures.
Reviews
Write Your Own Review