6-bromo-5-chloroquinoline
$400.00
CAS No.: 127827-53-6
Catalog No.: 192379
Purity: 95%
MF: C9H5BrClN
MW: 242.503
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C2C=CC=NC2=CC1)Cl
Catalog No.: 192379
Purity: 95%
MF: C9H5BrClN
MW: 242.503
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C2C=CC=NC2=CC1)Cl
6-bromo-5-chloroquinoline; CAS No.: 127827-53-6; 6-bromo-5-chloroquinoline. PROPERTIES: 6-bromo-5-chloroquinoline is a crystalline substance with molecular formula C9H5BrClN. It has a melting point of approximately 135-140 C and exhibits limited solubility in common organic solvents. The compound is light-sensitive and should be stored in amber glassware at 2-8 C. Safety precautions include wearing protective clothing due to its potential to cause skin burns and using explosion-proof ventilation due to its explosive nature when exposed to heat. APPLICATIONS: This brominated, chlorinated quinoline is used in the development of anticancer prodrugs. The bromine and chlorine substituents serve as reducible moieties that get activated in the tumor microenvironment as reported in cancer research literature. In chemical biology, 6-bromo-5-chloroquinoline serves as a building block for creating photoaffinity labels. According to biochemical journals, the quinoline scaffold provides a fluorescent signal while the bromine and chlorine groups enable photoinduced cross-linking with target proteins.
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