5-bromo-4-methoxy-1H-indazole
$250.00
CAS No.: 850363-67-6
Catalog No.: 192663
Purity: 95%
MF: C8H7BrN2O
MW: 227.061
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C2C=NNC2=CC1)OC
Catalog No.: 192663
Purity: 95%
MF: C8H7BrN2O
MW: 227.061
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=C2C=NNC2=CC1)OC
5-bromo-4-methoxy-1H-indazole; CAS No.: 850363-67-6; 5-bromo-4-methoxy-1H-indazole. PROPERTIES: This brominated, methoxy-substituted indazole has molecular formula C8H7BrN3O. It typically appears as a pale yellow crystalline solid. The 5-bromo-4-methoxy-1H-indazole demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 140-143 C, and it has a molecular weight of approximately 231.07 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may undergo demethylation upon exposure to aqueous conditions. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-bromo-4-methoxy-1H-indazole serves as a key intermediate in the synthesis of serotonin receptor agonists for psychiatric disorders where the methoxy group provides essential lipophilicity for blood-brain barrier penetration (as reported in pharmacology literature). The bromine atom enhances binding affinity through halogen bonding interactions. Additionally, the compound functions as a building block in the preparation of agrochemicals with herbicidal activity, though this application is mentioned only for informational purposes per your request. The methoxy group can be further functionalized through demethylation or alkylation reactions to produce various derivatives for chemical research applications.
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