5-fluoroquinoline-3-carbonitrile
$360.00
CAS No.: 2102412-57-5
Catalog No.: 192123
Purity: 95%
MF: C10H5FN2
MW: 172.162
Storage: 2-8 degree Celsius
SMILES: FC1=C2C=C(C=NC2=CC=C1)C#N
Catalog No.: 192123
Purity: 95%
MF: C10H5FN2
MW: 172.162
Storage: 2-8 degree Celsius
SMILES: FC1=C2C=C(C=NC2=CC=C1)C#N
5-fluoroquinoline-3-carbonitrile; CAS No.: 2102412-57-5; 5-fluoroquinoline-3-carbonitrile. PROPERTIES: 5-fluoroquinoline-3-carbonitrile is a pale yellow crystalline solid with molecular formula C11H6FN. It has a molar mass of 183.17 g/mol and exhibits limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 110-113 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical development, 5-fluoroquinoline-3-carbonitrile serves as a building block for creating antimicrobial agents. Research groups focusing on infectious diseases have used this compound to synthesize inhibitors of bacterial transcription machinery. The fluorine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing DNA intercalators. A study published in a cancer research journal demonstrated how derivatives of 5-fluoroquinoline-3-carbonitrile exhibited cytotoxicity against various cancer cell lines by intercalating into DNA and inhibiting replication. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 5-fluoroquinoline-3-carbonitrile derivatives into organic field-effect transistors to improve charge carrier mobility.
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