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1-(3-hydroxyquinolin-6-yl)ethanone; CAS No.: 1956341-14-2; 1-(3-hydroxyquinolin-6-yl)ethanone. PROPERTIES: 1-(3-hydroxyquinolin-6-yl)ethanone is a solid compound with a molecular weight of 221.7 g/mol. It has a melting point between 112 and 115 C and is moderately soluble in common organic solvents like methanol and ethyl acetate. The compound is sensitive to oxidation and should be stored under an inert atmosphere like nitrogen. It is stable under normal laboratory conditions but may decompose upon exposure to strong acids or bases. When handling, care should be taken to avoid skin contact and inhalation of vapors. APPLICATIONS: 1-(3-hydroxyquinolin-6-yl)ethanone serves as an important intermediate in the synthesis of quinoline-derived pharmaceuticals, particularly in the development of anti-inflammatory and analgesic agents. The hydroxyl group provides a site for further modification, such as esterification or ether formation. In medicinal chemistry, 1-(3-hydroxyquinolin-6-yl)ethanone is employed in the design of compounds targeting specific enzymatic pathways. It also functions as a building block in the synthesis of fluorescent probes for cellular imaging, where its quinoline core contributes to fluorescence properties. Additionally, the compound is used in the preparation of coordination compounds with metal ions for catalytic applications in organic transformations. These applications are typically encountered in pharmaceutical R&D laboratories and specialized chemical synthesis facilities.