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3-bromo-5-(methylsulfonyl)quinoline; CAS No.: 1956366-71-4; 3-bromo-5-(methylsulfonyl)quinoline. PROPERTIES: 3-bromo-5-(methylsulfonyl)quinoline is a crystalline powder with a molecular weight of 298.2 g/mol. It has a melting point between 128 and 131 C and is moderately soluble in polar organic solvents such as dimethylformamide and dimethyl sulfoxide. The compound is sensitive to light and should be stored in amber glass containers. It is stable at room temperature but may decompose upon prolonged exposure to high temperatures above 150 C. When handling, protective eyewear and gloves should be worn, and in case of eye contact, immediate rinsing with water is advised. APPLICATIONS: 3-bromo-5-(methylsulfonyl)quinoline functions as a versatile intermediate in the synthesis of pharmaceuticals, particularly in the development of anticancer and antiviral agents. The bromine substituent allows for diverse substitution reactions, while the methylsulfonyl group provides additional reactivity and selectivity. In medicinal chemistry, 3-bromo-5-(methylsulfonyl)quinoline is used to create compounds with improved solubility and bioavailability. It also serves as a building block in the synthesis of fluorescent dyes, where its quinoline core contributes to emission characteristics. Additionally, the compound is employed in the preparation of coordination compounds with metal ions for catalytic applications in organic synthesis. These uses are commonly found in pharmaceutical research institutions and chemical manufacturing facilities specializing in heterocyclic chemistry.