7-amino-2-methyl-quinazolin-4-ol
$650.00
CAS No.: 16081-78-0
Catalog No.: 197588
Purity: 95%
MF: C9H9N3O
MW: 175.191
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C2C(=NC(=NC2=C1)C)O
Catalog No.: 197588
Purity: 95%
MF: C9H9N3O
MW: 175.191
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C2C(=NC(=NC2=C1)C)O
7-amino-2-methyl-quinazolin-4-ol; CAS No.: 16081-78-0; 7-amino-2-methyl-quinazolin-4-ol. PROPERTIES: This amino-hydroxy-substituted quinazoline features molecular formula C?H?N?O? with molecular weight 164.16 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 120-125 C. Exhibits IR absorption for amine (~3300-3000 cm??) and hydroxyl groups (~3300 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an amino-hydroxy-substituted quinazoline, 7-amino-2-methyl-quinazolin-4-ol is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the amino and hydroxy groups provide enhanced binding affinity for the kinase hinge region as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its hydroxyl group forms covalent bonds with target biomolecules via oxime formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the quinazoline ring contributes to improved flame retardancy and mechanical properties (Polymer International).
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