4-hydroxyquinazolin-7-yl acetate
$995.00
CAS No.: 179246-13-0
Catalog No.: 197590
Purity: 95%
MF: C10H8N2O3
MW: 204.185
Storage: 2-8 degree Celsius
SMILES: C(C)(=O)OC1=CC=C2C(=NC=NC2=C1)O
Catalog No.: 197590
Purity: 95%
MF: C10H8N2O3
MW: 204.185
Storage: 2-8 degree Celsius
SMILES: C(C)(=O)OC1=CC=C2C(=NC=NC2=C1)O
4-hydroxyquinazolin-7-yl acetate; CAS No.: 179246-13-0; 4-hydroxyquinazolin-7-yl acetate. PROPERTIES: This hydroxy-substituted quinazoline acetate features molecular formula C??H?N?O? with molecular weight 219.19 g/mol. It generally appears as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 110-115 C. Exhibits IR absorption for ester (~1750 cm??) and hydroxyl groups (~3300 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a hydroxy-substituted quinazoline acetate, 4-hydroxyquinazolin-7-yl acetate is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the hydroxyl group provides enhanced binding affinity for the kinase hinge region as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its ester functionality enables conjugation to biomolecules via enzymatic hydrolysis (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the quinazoline ring contributes to improved flame retardancy and mechanical properties (Polymer International).
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