quinazoline-4,6-diamine
$400.00
CAS No.: 159382-23-7
Catalog No.: 197587
Purity: 95%
MF: C8H8N4
MW: 160.18
Storage: 2-8 degree Celsius
SMILES: N1=CN=C(C2=CC(=CC=C12)N)N
Catalog No.: 197587
Purity: 95%
MF: C8H8N4
MW: 160.18
Storage: 2-8 degree Celsius
SMILES: N1=CN=C(C2=CC(=CC=C12)N)N
quinazoline-4,6-diamine; CAS No.: 159382-23-7; quinazoline-4,6-diamine. PROPERTIES: This diamino-substituted quinazoline features molecular formula C?H?N? with molecular weight 164.18 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 130-135 C. Exhibits IR absorption for amine (~3300-3000 cm??) and aromatic C-H stretches. Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a diamino-substituted quinazoline, quinazoline-4,6-diamine is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the diamino groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its amine functionalities enable conjugation to fluorophores via reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the quinazoline ring contributes to improved flame retardancy and mechanical properties (Polymer International).
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