6-iodoquinazoline
$450.00
CAS No.: 848841-54-3
Catalog No.: 196007
Purity: 95%
MF: C8H5IN2
MW: 256.046
Storage: 2-8 degree Celsius
SMILES: IC=1C=C2C=NC=NC2=CC1
Catalog No.: 196007
Purity: 95%
MF: C8H5IN2
MW: 256.046
Storage: 2-8 degree Celsius
SMILES: IC=1C=C2C=NC=NC2=CC1
6-iodoquinazoline; CAS No.: 848841-54-3; 6-iodoquinazoline. PROPERTIES: 6-iodoquinazoline appears as a pale yellow crystalline solid with molecular formula C8H5IN2, exhibiting a molar mass of approximately 248.05 g/mol. Its solubility profile shows poor water miscibility but acceptable solubility in solvents like acetone and ethyl acetate. Thermal analysis indicates melting point in the range of 85-90 C. Proper storage mandates protection from light, moisture, and excessive heat, ideally maintained at 2-8 C in nitrogen or argon atmosphere. Safety considerations include classification as harmful if swallowed, causing skin irritation and serious eye damage. Safe handling requires full protective gear, and accidental release necessitates containment with inert materials followed by appropriate disposal per regulatory guidelines. APPLICATIONS: 6-iodoquinazoline functions prominently as a key intermediate in tyrosine kinase inhibitor development, particularly for compounds targeting cancer therapy. Its iodine substituent at position 6 facilitates Suzuki-Miyaura coupling reactions essential for constructing kinase inhibitor scaffolds. In academic research, the compound serves as a fluorescent probe precursor for studying nucleic acid interactions. Additionally, it contributes to the synthesis of agrochemical intermediates (non-agricultural applications), with methodologies described in Bioorganic & Medicinal Chemistry Letters and specialized chemical supplier catalogs, highlighting its utility across multiple scientific disciplines.
Reviews
Write Your Own Review