2,6-dibromoquinazoline
$400.00
CAS No.: 161425-75-8
Catalog No.: 196005
Purity: 95%
MF: C8H4Br2N2
MW: 287.942
Storage: 2-8 degree Celsius
SMILES: BrC1=NC2=CC=C(C=C2C=N1)Br
Catalog No.: 196005
Purity: 95%
MF: C8H4Br2N2
MW: 287.942
Storage: 2-8 degree Celsius
SMILES: BrC1=NC2=CC=C(C=C2C=N1)Br
2,6-dibromoquinazoline; CAS No.: 161425-75-8; 2,6-dibromoquinazoline. PROPERTIES: 2,6-dibromoquinazoline presents as a white to off-white crystalline powder with molecular formula C8H4Br2N2 and molar mass ~271.84 g/mol. It demonstrates limited aqueous solubility but dissolves reasonably well in polar aprotic solvents. Melting point observations typically fall within 118-122 C. The compound's stability profile requires protective storage measures: amber glass containers, desiccant inclusion, and temperature control below 20 C. Occupational safety considerations involve engineering controls like fume hoods and administrative practices limiting exposure duration. Skin contact warrants immediate washing, and eye contact requires thorough rinsing and medical attention. APPLICATIONS: This di-brominated quinazoline derivative excels as a versatile intermediate in pharmaceutical manufacturing. Its regioisomeric bromine placement at positions 2 and 6 enables selective cross-coupling reactions crucial for synthesizing EGFR and FGFR inhibitors. In materials science, 2,6-dibromoquinazoline contributes to semiconductor dopant development through controlled polymerization processes. The compound additionally supports research into bacterial efflux pump inhibitors, with applications documented in Organic Process Research & Development and medicinal chemistry patents, illustrating its significance in both therapeutic agent design and materials innovation.
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