6-iodoquinazolin-4-amine
$750.00
CAS No.: 182880-14-4
Catalog No.: 197591
Purity: 95%
MF: C8H6IN3
MW: 271.061
Storage: 2-8 degree Celsius
SMILES: IC=1C=C2C(=NC=NC2=CC1)N
Catalog No.: 197591
Purity: 95%
MF: C8H6IN3
MW: 271.061
Storage: 2-8 degree Celsius
SMILES: IC=1C=C2C(=NC=NC2=CC1)N
6-iodoquinazolin-4-amine; CAS No.: 182880-14-4; 6-iodoquinazolin-4-amine. PROPERTIES: This iodo-substituted quinazolinamine features molecular formula C?H?N?OI with molecular weight 263.07 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 120-125 C. Exhibits IR absorption for amine (~3300-3000 cm??) and C-I groups (~550-450 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As an iodo-substituted quinazolinamine, 6-iodoquinazolin-4-amine is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the iodo substituent provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its amine functionality enables conjugation to fluorophores via reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the iodo substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
Reviews
Write Your Own Review