4-chloro-6-methoxy-2-methyl-quinazoline
$400.00
CAS No.: 60395-90-6
Catalog No.: 197596
Purity: 95%
MF: C10H9ClN2O
MW: 208.648
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC=C(C=C12)OC)C
Catalog No.: 197596
Purity: 95%
MF: C10H9ClN2O
MW: 208.648
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC=C(C=C12)OC)C
4-chloro-6-methoxy-2-methyl-quinazoline; CAS No.: 60395-90-6; 4-chloro-6-methoxy-2-methyl-quinazoline. PROPERTIES: This chloro-methoxy-methyl-substituted quinazoline features molecular formula C?H?ClN?O with molecular weight 205.64 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 100-105 C. Exhibits IR absorption for C-Cl (~600-500 cm??) and C-O stretches (~1300-1000 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a chloro-methoxy-methyl-substituted quinazoline, 4-chloro-6-methoxy-2-methyl-quinazoline is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the chloro, methoxy, and methyl groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its quinazoline framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the methoxy substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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