6-nitroquinazolin-4-amine
$270.00
CAS No.: 49675-68-5
Catalog No.: 197595
Purity: 95%
MF: C8H6N4O2
MW: 190.162
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=C2C(=NC=NC2=CC1)N
Catalog No.: 197595
Purity: 95%
MF: C8H6N4O2
MW: 190.162
Storage: 2-8 degree Celsius
SMILES: [N+](=O)([O-])C=1C=C2C(=NC=NC2=CC1)N
6-nitroquinazolin-4-amine; CAS No.: 49675-68-5; 6-nitroquinazolin-4-amine. PROPERTIES: This nitro-substituted quinazolinamine features molecular formula C?H?N?O? with molecular weight 186.16 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 130-135 C. Exhibits IR absorption for amine (~3300-3000 cm??) and nitro groups (~1520 and ~1350 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a nitro-substituted quinazolinamine, 6-nitroquinazolin-4-amine is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the nitro group provides enhanced binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its nitro group enhances solubility and binding affinity for target biomolecules (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the quinazoline ring contributes to improved flame retardancy and mechanical properties (Polymer International).
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