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1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride
$600.00
CAS No.: 100960-08-5
Catalog No.: 196487
Purity: 95%
MF: C7H8ClN3
MW: 169.615
Storage: 2-8 degree Celsius
SMILES: Cl.N1C=C(C=2C1=NC=CC2)N
Catalog No.: 196487
Purity: 95%
MF: C7H8ClN3
MW: 169.615
Storage: 2-8 degree Celsius
SMILES: Cl.N1C=C(C=2C1=NC=CC2)N
1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride; CAS No.: 100960-08-5; 1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride. PROPERTIES: 1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride appears as a white to off-white crystalline powder. Its molecular formula is C8H7N3.HCl, corresponding to a molecular weight of 185.62 g/mol. The compound is highly soluble in water and polar organic solvents such as methanol and ethanol. It has a melting point typically ranging from 205-210 C (decomposition) and is stable under ambient conditions when stored properly. Recommended storage involves keeping the material in a tightly sealed container at room temperature (15-25 C), preferably in a cool, dry, and well-ventilated area away from direct sunlight and moisture. The compound is hygroscopic and should be protected from excessive humidity. Safety precautions include wearing appropriate personal protective equipment such as chemical-resistant gloves, eye protection, and lab coats when handling the material. In case of skin contact, thorough washing with water is recommended, and eye contact requires immediate rinsing with water for at least 15 minutes followed by medical attention if necessary. The compound should be handled in well-ventilated areas to avoid inhalation of dust particles. APPLICATIONS: 1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride serves as a key intermediate in pharmaceutical synthesis, particularly in the development of novel antiviral and anticancer agents. Its unique heterocyclic framework provides valuable bioisosteric properties that enhance binding affinity to various biological targets. In medicinal chemistry, the compound has been utilized in the synthesis of viral protease inhibitors and as a core structure in the design of kinase inhibitors targeting oncogenic pathways, as documented in several pharmaceutical research publications. The pyrrolopyridine system offers versatile functionalization sites that facilitate the introduction of substituents to modulate solubility, metabolic stability, and target specificity. Additionally, 1H-pyrrolo[2,3-b]pyridin-3-amine hydrochloride finds application in materials science as a building block for organic semiconductors and in the development of fluorescent probes for bioimaging applications. Its utility extends to analytical chemistry, where it serves as a reference standard for chromatographic analyses and as a starting material for custom syntheses in specialized laboratories focusing on heterocyclic chemistry and medicinal applications.
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