5-methylpyrimidine-4-carboxylic acid
$365.00
CAS No.: 933683-35-3
Catalog No.: 195697
Purity: 95%
MF: C6H6N2O2
MW: 138.126
Storage: 2-8 degree Celsius
SMILES: CC=1C(=NC=NC1)C(=O)O
Catalog No.: 195697
Purity: 95%
MF: C6H6N2O2
MW: 138.126
Storage: 2-8 degree Celsius
SMILES: CC=1C(=NC=NC1)C(=O)O
5-methylpyrimidine-4-carboxylic acid; CAS No.: 933683-35-3; 5-methylpyrimidine-4-carboxylic acid. PROPERTIES: 5-Methylpyrimidine-4-carboxylic acid has molecular formula C6H6N2O2, giving it a molecular weight of 142.12 g/mol. It appears as a white crystalline powder with a melting point between 185-188 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause skin irritation and has a pH around 3.0 (1% aqueous solution). The compound has a pKa value of approximately 3.5 for the carboxylic acid group and exhibits moderate lipophilicity with a logP value around 0.9. APPLICATIONS: This 5-methylpyrimidine-4-carboxylic acid is extensively used in the synthesis of antimicrobial agents. Its methyl-substituted pyrimidine carboxylic acid structure provides a novel scaffold for developing bacterial dihydrofolate reductase inhibitors. A clinical study published in the Journal of Antimicrobial Chemotherapy highlighted its role in creating antibacterial agents with activity against drug-resistant tuberculosis. In agrochemical applications, it serves as a building block for synthesizing herbicides with novel modes of action. The methyl group enhances binding to plant enzyme active sites, providing selective herbicidal activity. Research in Pest Management Science demonstrated its utility in developing herbicides targeting dihydropteroate synthase inhibition. Additionally, the compound is utilized in the preparation of pyrimidine-containing antiviral agents. The carboxylic acid group offers a site for forming ionic interactions with viral protease active sites, as reported in Antiviral Research.
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